ALZHEIMER: Men, women, inequality in the face of the disease

ALZHEIMER: Men, women, inequality in the face of the disease

Lead author Dr. Richard Isaacson, director of FAU’s Alzheimer’s Prevention Clinic, along with colleagues at Weill Cornell Medicine in New York, tracked the number of factors in Alzheimer’s patients over time and interventions to assess response to therapies and optimize lifestyle programs, including exercise and nutrition. for these patients.

Gender has a significant effect on intervention outcomes

Tracking response to tailored interventions, by gender: While previous studies have analyzed the influence of hormones on the incidence of the disease, this research analyzed the response to different interventions, personalized for each patient and according to gender.

These personalized interventions included patient education (PTE), genetic counseling, individualized pharmacological approaches (medications/vitamins/supplements), non-pharmacological approaches (exercise advice, dietary advice, vascular risk reduction, sleep hygiene, cognitive compromise, stress, and general medical care). care) and other evidence-based interventions.

Therefore, the researchers followed the evolution of the risk of Alzheimer’s disease, as well as that of certain blood markers of risk, in response to interventions against the disease. The same team had previously shown that individualized and multidomain interventions can improve cognition and reduce the risk of Alzheimer’s disease in both women and men. The analysis finds that:

  • individualized interventions for risk reduction or prevention of Alzheimer’s disease lead to improvements in cognition in women and men;
  • however, women respond better to these interventions, in several areas of health, including the prevention of atherosclerosis, the reduction of cardiovascular risk, the slowing of the aging process as well as the prevention of the risk of dementia at the end of life, as well as evaluated by middle-aged “cerebrovascular” markers (BMI, blood pressure, cholesterol levels, and smoking). In other words, lifestyle interventions known to help reduce Alzheimer’s risk in later life appear to induce a more significant response in women than in men.
  • with greater improvements in women versus men on risk scales for Alzheimer’s disease and cardiovascular disease,
  • with better levels of risk biomarkers in the blood (glycemia, LDL cholesterol, and HbA1C), again in women compared to men.

The implications are important in terms of public health. while women are disproportionately affected by Alzheimer’s disease and managing preventable risk factors, primarily lifestyle, can

prevent up to a third of dementia cases.

Thus, the study confirms that if there is no simple treatment -such as a drug- for the disease, the approach of individualized management of the disease can provide cognitive advantages to women and men, but will significantly reduce the risk of Alzheimer’s and Alzheimer’s disease. cardiovascular disease in women than in men.

The authors now call for larger studies that better account for these gender differences in cognitive trajectories and allow management programs to be refined by taking patient gender into account.

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